АНАЛИЗ ЭФФЕКТИВНОСТИ НОВОГО ПРЕПАРАТА НА ОСНОВЕ ГАНОДЕРМЫ ЛУЦИДУМ И АЛХАДАЯ В ЛЕЧЕНИИ КОРОНАВИРУСНОЙ ИНФЕКЦИИ, ВЫЗВАННОЙ COVID-19
Ключевые слова:
коронавирусная инфекция SARS CoV-2, препараты на основе G. lucidum и Алхадая (масло черного тмина).Аннотация
Maqsad: SARS CoV-2 koronavirus infektsiyasini G. lucidum va Alxadai asosidagi yangi preparat bilan davolash natijalarini qiyosiy prospektiv randomize o'rganish. Material va usullar: tajribalar ikkala jinsdagi 200 ta etuk kalamushlarda o'tkazildi. 160 ta kalamush koronavirus infeksiyasi bilan kasallangan. Hayvonlar oziq-ovqat va suvga erkin kirish imkoniyati va kun va tunning tabiiy o'zgarishi bilan vivariumda saqlangan. Tajribalar o'z- o'zidan nafas olish va atrof-muhit harorati 24- 25°С sharoitida amalga oshirildi. Natijalar: ma'lumki, matritsa metalloproteinazalarining yuzasida Zn bilan bog'langan domen va ECMning (hujayra ichidagi matritsa) halokatli komponentlari mavjud. Ganoderma lucidum, shuningdek, matritsali metalloproteinazalarning to'qima ingibitorlari orqali ushbu proteazlarning kiruvchi ta'sirini boshqaradigan membrana bilan bog'langan ADAM metalloproteinazalariga ham ta'sir qiladi. Ma'lum bo'lishicha, mezbon organizm qalqonsimon bezning parafollikulyar C-hujayralari ushbu retseptorlarni muvozanatda ushlab turishga qodir emasligi sababli ushbu virusni yanada ko'proq ishlab chiqarishni rag'batlantiradi. Xulosa: G. lucidum va Alxadai asosidagi yangi dori vositasidan foydalanish COVID-19 keltirib chiqaradigan koronavirus infeksiyasiga qarshi samarali bo‘lib, tadqiqotda isbotlanganidek, hech qanday nojo‘ya ta’sirga ega emas.
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