Results of frequency analysis distribution of polymorphism rs1800895 592c> a in IL10 gene among patients with CRSWP

Results of frequency analysis distribution of polymorphism rs1800895 592c> a in IL10 gene among patients with CRSWP


  • U.S. Khasanov Tashkent Medical Academy
  • J.А. Djuraev Tashkent Medical Academy
  • A.Z. Shaumarov Tashkent Medical Academy
  • U.P. Abdullaev Tashkent Medical Academy
  • Kh.O. Khojisaliev Tashkent Medical Academy
  • B. Zulunov Tashkent Medical Academy
  • Sh. Ibodullaev Tashkent Medical Academy



chronic polyposis rhinosinusitis, gene, polymorphism, allele, locus


Chronic polyposis rhinosinusitis (CRSwP) is classified as an urgent problem of otorhinolaryngology due to the high prevalence of the disease and its medico-social significance. This article presents the results of genetic studies of rs1800895 592C> A polymorphism in the IL10 gene in patients with CRSwP. Material and methods. In accordance with the purpose of the study and to fulfill the assigned tasks, clinical studies were carried out in 140 patients with CRSwP and chronic rhinosinusitis who were examined and treated at the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy in 2017-2020. Results. Summarizing the results obtained, we can conclude that there are no significant differences in the frequency of detection of allelic and genotypic variants of the rs1800895 592 C>A polymorphic locus in the IL10 gene in groups 1 and 2 of patients. There is no significant contribution of this locus to the formation and development of one or another form of XPC. However, in CRSwP patients, in comparison with the control group, there is a significant tendency to a decrease in the frequency of the A/A genotype. According to the odds ratio, the risk of CRSwP formation in carriers of this genotype is increased by 2.4 times (χ2=14.71; Р=0.70; RR=0.83; OR=0.14; 95% CI:1.78-0.39).


Congxiang Shen, Fang Chen, Huigang Wang, Xinyu Zhang, Guanxue Li, Zhong Wen. Individualized treatment for allergic rhinitis based on key nasal clinical manifestations combined with histamine and leukotriene D4 levels,Brazilian Journal of Otorhinolaryngology,2018

E.P. Resende, A. Todo-Bom, C. Loureiro, A. Mota Pinto, B. Oliveiros, L. Mesquita, H.C. Silva. Asthma and rhinitis have different genetic profiles for IL13, IL17A and GSTP1 polymorphisms,Revista Portuguesa de Pneumologia (English Edition),Volume 23, Issue 1,2017,Pages 10-16

Fabiana C.P. Valera, Leandra M. Endam, Badr Ibrahim, Emmanuelle Brochiero, Martin Y. Desrosiers. Is there a role for regenerative medicine in chronic rhinosinusitis with nasal polyps?,Brazilian Journal of Otorhinolaryngology,Volume 83, Issue 1,2017,Pages 1-2

Gary N. Gross, Gary Berman, Niran J. Amar, Cynthia F. Caracta, Sudeesh K. Tantry. Efficacy and safety of olopatadine-mometasone combination nasal spray for the treatment of seasonal allergic rhinitis. Annals of Allergy, Asthma & Immunology,Volume 122, Issue 6,2019,Pages 630-638

J.J. Braun, S. Riehm. Anosmia and nasal obstruction,European Annals of Otorhinolaryngology, Head and Neck Diseases,Volume 135, Issue 3,2018,Pages 217-219

Manuela Dowsley A. Guttemberg, Fabiana A. Figueiredo da Mata, Márcio Nakanishi, Keitty R.C. de Andrade, Maurício G. Pereira. Sleep quality assessment in chronic rhinosinusitis patients submitted to endoscopic sinus surgery: a meta-analysis,Brazilian Journal of Otorhinolaryngology,2019