O'tkir sensonevral eshitish zaifligi bo'lgan bemorlarda allellar va gen polimorfizmlarining genotiplarini aniqlash chastotlarining qiyosiy ta'rifi
Ключевые слова:
gen polimorfizmi, sensonevral eshitish pasayishi, audiometriyaАннотация
Bizning ma'lumotlarimiz qon tomir genezisning o'tkir sensorinöral eshitish qobiliyatini yo'qotgan bemorlarda O'SNEZ rivojlanishining genetik mexanizmining murakkabligini tasdiqlaydi va o'rganilayotgan patologiyaning rivojlanishi va klinik bosqichini tahlil qilishda genlarning murakkab o'zaro ta'sirini tushunish zarurati va ahamiyatini ko'rsatadi. Ushbu polimorfizmning genotipik variantlarining tarqalishini tahlil qilib, VEGF-A genidagi C-634G rs2010963 polimorfizmi G/G monogenotipining O'SNEZ rivojlanishi bilan bog'liqligini aniqladik. Qon tomir O'SNEZ bilan og'rigan bemorlarning 1-guruhida VEGF-A genida C-634G rs2010963 polimorfizmining kichik genotipining chastotasini oshirish tendentsiyasi mavjud (ch2 = 4,6; P = 0,30; RR = 2,15; OR = 1,1). 95% CI: 2.174-6.69) nazorat guruhi bilan solishtirganda kuzatildi. Bunday holda, 1-guruhdagi bemorlarning ko'rsatkichlari ajratilib, nazorat guruhi bilan taqqoslandi va OR va RR ko'rsatkichlari ortdi va G/G genotiplarida ishonchlilik darajasi sezilarli darajada oshdi (ch2 =0,39; P=0,29; RR=2,35; OR=2,4; 95% CI: 37,929-36,50).
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