Результаты анализа частоты распределение полиморфизма rs1800895 592c>a в гене IL10 среди больных с ХПРС

Abstract

Chronic polyposis rhinosinusitis (CRSwP) is classified as an urgent problem of otorhinolaryngology due to the high prevalence of the disease and its medico-social significance. This article presents the results of genetic studies of rs1800895 592C> A polymorphism in the IL10 gene in patients with CRSwP. Material and methods. In accordance with the purpose of the study and to fulfill the assigned tasks, clinical studies were carried out in 140 patients with CRSwP and chronic rhinosinusitis who were examined and treated at the ENT department of the multidisciplinary clinic of the Tashkent Medical Academy in 2017-2020. Results. Summarizing the results obtained, we can conclude that there are no significant differences in the frequency of detection of allelic and genotypic variants of the rs1800895 592 C>A polymorphic locus in the IL10 gene in groups 1 and 2 of patients. There is no significant contribution of this locus to the formation and development of one or another form of XPC. However, in CRSwP patients, in comparison with the control group, there is a significant tendency to a decrease in the frequency of the A/A genotype. According to the odds ratio, the risk of CRSwP formation in carriers of this genotype is increased by 2.4 times (χ2=14.71; Р=0.70; RR=0.83; OR=0.14; 95% CI:1.78-0.39).