Influences of IL-1 and VEGF-A cytokines in acute sensoneural hearing loss
Keywords:
cytokine, sensorineural hearing loss, steroid therapyAbstract
The study of cytokine regulation is of great importance in predicting the development of irreversible changes in the auditory analyzer as a result of OSNEZ and in assessing the effectiveness of the therapeutic interventions. The level of VEGF-A in the blood of practically healthy people was 0.89 (0.6; 2.7) ng/ml, with a minimum value of 0.30 ng/ml and a maximum of 32.8 ng/ml. During our study, it was observed that the level of the studied indicator in patients with OSNEZ was almost 100 times higher than in healthy people. In group 1 of patients with OSNEZ who received complex therapy and GBO, the VEGF-A level during hospitalization was 310.1 (127.4; 320.5) ng/ml, with a minimum and maximum value of 120.5 and 335.8 ng/ml, respectively. In group 2 of patients with OSNEZ who received complex therapy and intratympanic steroid therapy, the VEGF-A level was 193.2 (152.2; 169.4) ng/ml, with individual variations from 50.8 to 188.2 ng/ml.
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