Comparative study of the microbial landscape in patients with recurrent inflammation of the nasal cavity and paranasal sinuses (using the example of bacterial and viral rhinosinusitis)
Keywords:
microorganisms, rhinosinusitis, nasal cavity, paranasal sinusesAbstract
In recent years, the etiological role of bacterial microflora in recurrent inflammatory diseases has been the subject of intense discussions. To understand the self-regulatory processes in the nasal mucosa, nasopharynx, and upper respiratory tract during the formation of microbiocenosis, it is necessary to know the nature of the relationship between populations of different types of microorganisms. Goal: provide a comparative microbiological characterization of the nasal mucosa and paranasal sinuses in patients with recurrent inflammation of various origins. The study included 52 patients of both genders aged 20 to 65 years with symptoms of inflammatory diseases of the nasal cavity and paranasal sinuses. Of these, 28 patients (1st group) with bacterial and 24 patients (2nd group) with recurrent viral inflammatory diseases of the nasal cavity and paranasal sinuses (ARVI). A comparative analysis of the microbial landscape of the nasal mucosa and paranasal sinuses revealed the main representatives of the pathogenic flora, as well as associations of microorganisms. Monoculture predominates in the paranasal sinuses - 69.3% (34 people), and microbial associations make up 26.9% (14 people), lack of microflora - 5.7% (3 people). The presence of Proteus vulgaris strain - 4 cases (8.1%), E.coli - 8 cases (16.3%), Pseudomonas aeruginosa - 7 cases (14.2%) was particularly significant, the increase in the proportion of Candida yeast-like fungi in the microbial landscape of patients with VR attracts attention. Among yeast-like fungi, C. albicans was the most common in 33 (67.3%) and C. glabrata in 5 (10.2%) cases.
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